researchers have found some risk factors that increase a persons risk of anal cancer, but the exact cause of anal cancer is not known. Most anal cancers seem to be linked to infection with the human papillomavirus (hpv). While hpv infection seems to be important in the development of anal cancer, the vast majority of people with hpv infections do not get anal cancer. according to surveillance, epidemiology and end results (seer) data, the annual incidence rate of new anal cancer cases from 2011-2015 was 1. 8 per 100,000 men and women per year, while the number of deaths was 0. The lifetime risk of developing anal cancer, according to 2013-2015 seer data, is 0. Aetiological parallel between anal cancer and cervical cancer. Malignancies that occur before and after anal cancer clues to their etiology. Has increased among both men (160) and women (78) from 1973 to 2000. 1, 2 although the incidence was consistently higher for women compared with men through 1995, the annual incidence from 1996 to 2000 was equal for men and women (2. 1 human papillomaviruses (hpv) have been implicated as a cause of cervical and other. Anal cancer is an uncommon malignancy that starts in the anus-- the opening at the end of the rectum. The american society of clinical oncology estimates that 8,300 cases of anal cancer will be. Your risk of developing anal cancer increases as you get older. Around 25 out of 100 people (around 25) diagnosed with anal cancer each year in the uk are aged 75 and over. Risk factors include infection with human papillomavirus (), immunodeficiency, and receptive anal intercourse. The most common clinical features are rectal bleeding (up to 45 of cases), pruritus ani, and tenderness or pain in the anal area. Anal cancer presents mainly as squamous cell carcinoma and in rare cases as adenocarcinoma or other non-epidermoid cancers.